Differential immune responses to HIV-1 envelope protein induced by liposomal adjuvant formulations containing monophosphoryl lipid A with or without QS21. Issue 42 (13th October 2015)

• Record Type: Journal Article
• Authors: Beck, Zoltan; Matyas, Gary R.; Jalah, Rashmi; Rao, Mangala; Polonis, Victoria R.; Alving, Carl R.
• Is Part Of: Vaccine. Volume 33:Issue 42(2015)
• Page Start: 5578
• Page End: 5587
• Publication Date: 2015-10-13
• Subjects: Vaccines -- Periodicals; 615.372
• DOI: 10.1016/j.vaccine.2015.09.001
• Languages: English
• ISSNs: 0264-410X

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0005"> <list id="lis0005"> <list-item id="lsti0005"> <label></label> <p id="par0005">Structural changes were made in Army Liposome Formulations (ALF) containing MPLA.</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010">Small ALF liposomes induced higher antibody titers than large ALF liposomes.</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0015">QS21 converted small ALF liposomes to large ALFQ particles.</p> </list-item> <list-item id="lsti0020"> <label></label> <p id="par0020">ALF induced mainly IL-4 secretion and ALFQ induced both IFN-γ and IL-4.</p> </list-item> <list-item id="lsti0025"> <label></label> <p id="par0025">ALF and ALFQ both induced neutralizing antibodies to CN54 gp140.</p> </list-item> </list> </p> </sec> </abstract>