Effect of topical ophthalmic dorzolamide(2%)–timolol(0.5%) solution and ointment on intraocular pressure in normal horses. (18th December 2014)

• Record Type: Journal Article
• Authors: Tofflemire, Kyle L.; Whitley, Elizabeth M.; Flinn, Allison M.; Dufour, Valerie L.; Ben‐Shlomo, Gil; Allbaugh, Rachel A.; Griggs, Angela N.; Peterson, Chimene S.; Whitley, David R.
• Is Part Of: Veterinary ophthalmology. Volume 18:Number 6(2015)
• Page Start: 457
• Page End: 461
• Publication Date: 2014-12-18
• Subjects: Veterinary ophthalmology -- Periodicals; 636.08977
• DOI: 10.1111/vop.12242
• Languages: English
• ISSNs: 1463-5216

Abstract

<abstract abstract-type="main" id="vop12242-abs-0001"> <title>Abstract</title> <sec id="vop12242-sec-0001" sec-type="section"> <title>Objective</title> <p>To compare the effect of commercially available solution and compounded ointment formulations of dorzolamide(2%)–timolol(0.5%) on intraocular pressure (IOP) of normal horses.</p> </sec> <sec id="vop12242-sec-0002" sec-type="section"> <title>Animals</title> <p>Eighteen clinically normal horses.</p> </sec> <sec id="vop12242-sec-0003" sec-type="section"> <title>Procedures</title> <p>A randomized, masked prospective design was used with horses divided into two equal groups. One eye of each horse was selected for topical ophthalmic treatment with either 0.2 mL of dorzolamide(2%)–timolol(0.5%) solution or 0.2 g of dorzolamide(2%)–timolol(0.5%) ointment every 12 h for 5 days. The contralateral eye of horses in both groups was untreated. Rebound tonometry was performed every 6 h starting 2 days prior to and ending 2 days after the treatment period.</p> </sec> <sec id="vop12242-sec-0004" sec-type="section"> <title>Results</title> <p>The mean IOP reduction in eyes treated with the solution or ointment formulations was 13%. Untreated eyes in both groups experienced a lesser but still statistically significant reduction in IOP. The IOP values did not return to baseline within 48 h of the last treatment.</p> </sec> <sec id="vop12242-sec-0005" sec-type="section"> <title>Conclusions and Clinical Relevance</title> <p>The commercially available solution and compounded ointment formulations of ophthalmic dorzolamide(2%)–timolol(0.5%) had similar effects on IOP in normal horses. Persistent IOP reduction following cessation of treatment may indicate prolonged drug effect or acclimation of horses to tonometry.</p> </sec> </abstract>