MITF is a critical regulator of the carcinoembryonic antigen‐related cell adhesion molecule 1 (CEACAM1) in malignant melanoma. (November 2015)

• Record Type: Journal Article
• Authors: Ullrich, Nico; Löffek, Stefanie; Horn, Susanne; Ennen, Marie; Sánchez‐del‐Campo, Luis; Zhao, Fang; Breitenbuecher, Frank; Davidson, Irwin; Singer, Bernhard B.; Schadendorf, Dirk; Goding, Colin R.; Helfrich, Iris
• Is Part Of: Pigment cell & melanoma research. Volume 28:Number 6(2015:Nov.)
• Page Start: 736
• Page End: 740
• Publication Date: 2015-11
• Subjects: Melanoma -- Periodicals; Chromatophores -- Periodicals; Animal pigments -- Periodicals; 616.99477
• DOI: 10.1111/pcmr.12414
• Languages: English
• ISSNs: 1755-1471

Abstract

<abstract abstract-type="main" id="pcmr12414-abs-0001"> <title>Summary</title> <p>The multifunctional Ig‐like carcinoembryonic antigen‐related cell adhesion molecule 1 (CEACAM1) is neo‐expressed in the majority of malignant melanoma lesions. CEACAM1 acts as a driver of tumor cell invasion, and its expression correlates with poor patient prognosis. Despite its importance in melanoma progression, how <italic>CEACAM1</italic> expression is regulated is largely unknown. Here, we show that <italic>CEACAM1</italic> expression in melanoma cell lines and melanoma tissue strongly correlates with that of the microphthalmia‐associated transcription factor (MITF), a key regulator of melanoma proliferation and invasiveness. MITF is revealed as a direct and positive regulator for <italic>CEACAM1</italic> expression via binding to an M‐box motif located in the <italic>CEACAM1</italic> promoter. Taken together, our study provides novel insights into the regulation of <italic>CEACAM1</italic> expression and suggests an MITF‐CEACAM1 axis as a potential determinant of melanoma progression.</p> </abstract>