Neuronal Nitric Oxide Synthase (nNOS, NOS1) rs693534 and rs7977109 Variants and Risk for Migraine. Issue 9 (18th August 2015)

• Record Type: Journal Article
• Authors: García‐Martín, Elena; Martínez, Carmen; Serrador, Mercedes; Alonso‐Navarro, Hortensia; Navacerrada, Francisco; García‐Albea, Esteban; Agúndez, José A.G.; Jiménez‐Jiménez, Félix Javier
• Is Part Of: Headache. Volume 55:Issue 9(2015)
• Page Start: 1209
• Page End: 1217
• Publication Date: 2015-08-18
• Subjects: Headache -- Periodicals; Headache -- Periodicals; 616.8491
• DOI: 10.1111/head.12617
• Languages: English
• ISSNs: 0017-8748

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="head12617-sec-0001" sec-type="section"> <title>Background/Objectives</title> <p>Many biochemical, pharmacological, neuropathological, and experimental data suggest a possible role of nitric oxide in the pathogenesis of migraine. We investigated the possible association between functional single nucleotide polymorphisms (SNPs) in the <italic>neuronal nitric oxide synthase</italic> gene (<italic>NOS</italic><italic>1</italic> or <italic>nNOS</italic>; chromosome 12q24.22) and the risk for migraine.</p> </sec> <sec id="head12617-sec-0002" sec-type="section"> <title>Methods</title> <p>We studied the frequency of the of rs7977109 and rs693534 genotypes and allelic variants in 197 patients with migraine and 308 healthy controls using a <italic>T</italic><italic>aq</italic><italic>M</italic><italic>an</italic>‐based qPCR assay. As a secondary analysis, we studied the possible influence of gender, age at onset of migraine, positive family history of migraine, and presence or absence of aura on the genotypes frequency.</p> </sec> <sec id="head12617-sec-0003" sec-type="section"> <title>Results</title> <p>The frequencies of rs7977109 and rs693534 genotypes and allelic variants were not associated with the risk for migraine with OR for minor alleles = 0.94 (95% CI 0.72‐1.23) and = 0.88 (0.68‐1.15), respectively, and the lack of association was not influenced by gender, age at onset of migraine, positive family history of migraine, and presence or absence of aura.</p> </sec> <sec id="head12617-sec-0004" sec-type="section"> <title>Conclusion</title> <p> <italic>NOS</italic> <italic>1</italic> rs7977109 and rs693534 genotypes and allelic variants are not associated with the risk for migraine in Caucasian Spanish people.</p> </sec> </abstract>