Nasal endoscopic evaluation and its impact on survival in patients with stage I/II extranodal natural killer/T‐cell lymphoma, nasal type. Issue 10 (3rd June 2015)

• Record Type: Journal Article
• Authors: Cho, Hyun‐Jin; Jang, Min‐Seok; Hong, Sang Duk; Kim, Seok Jin; Ahn, Yong Chan; Oh, Dongryul; Ko, Young Hyeh; Kim, Hyo Yeol; Dhong, Hun‐Jong; Chung, Seung‐Kyu; Kim, Won Seog
• Is Part Of: International forum of allergy & rhinology. Volume 5:Issue 10(2015:Oct.)
• Page Start: 960
• Page End: 966
• Publication Date: 2015-06-03
• Subjects: 617.51005
• DOI: 10.1002/alr.21564
• Languages: English
• ISSNs: 2042-6976

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="alr21564-sec-0010" sec-type="section"> <title>Background</title> <p>Endoscopic findings of extranodal natural killer/T‐cell lymphoma (ENKTL), nasal type, are heterogeneous, but not fully understood. The objective of this study was to evaluate the role of nasal endoscopic examination and its implications for treatment of stage I/II ENKTL.</p> </sec> <sec id="alr21564-sec-0020" sec-type="section"> <title>Methods</title> <p>This retrospective study included 60 consecutive patients diagnosed with stage I/II ENKTL, nasal type, from 2000 to 2011.</p> </sec> <sec id="alr21564-sec-0030" sec-type="section"> <title>Results</title> <p>The endoscopic findings were classified into early (45%) and advanced (55%) lesions. Furthermore, the primary tumor extent assessed by endoscopy was significantly correlated with the radiologic imaging (<italic>p</italic> < 0.001). The results of univariate analysis showed that the patients with advanced lesions had worse overall survival (<italic>p</italic> = 0.004) and disease‐free survival (<italic>p</italic> = 0.001) than those with early lesions. In multivariate analysis, advanced lesions on nasal endoscopy was an independent prognostic factor (<italic>p</italic> = 0.024; hazard ratio 5.29; 95% confidence interval, 1.25–22.39).</p> </sec> <sec id="alr21564-sec-0040" sec-type="section"> <title>Conclusion</title> <p>We found that nasal endoscopic findings were important prognostic factors in stage I/II ENKTL, nasal type, suggesting that comprehensive endoscopic evaluation of primary tumor should be performed in this setting.</p> </sec> </abstract>