Reactivity to sorbitan sesquioleate affects reactivity to fragrance mix I. (28th August 2015)

• Record Type: Journal Article
• Authors: Geier, Johannes; Schnuch, Axel; Lessmann, Holger; Uter, Wolfgang
• Is Part Of: Contact dermatitis. Volume 73:Number 5(2015:Nov.)
• Page Start: 296
• Page End: 304
• Publication Date: 2015-08-28
• Subjects: Contact dermatitis -- Periodicals; 616.51
• DOI: 10.1111/cod.12468
• Languages: English
• ISSNs: 0105-1873

Abstract

<abstract abstract-type="main" id="cod12468-abs-0001"> <title>Summary</title> <sec id="cod12468-sec-0001" sec-type="section"> <title>Background</title> <p id="cod12468-para-0001">Fragrance mix I (FM I) and its single constituents contain 5% and 1% sorbitan sesquioleate (SSO), respectively. SSO is a rare sensitizer and a potential irritant.</p> </sec> <sec id="cod12468-sec-0002" sec-type="section"> <title>Objectives</title> <p id="cod12468-para-0002">To determine whether the outcome of the FM I breakdown test is affected by positive patch test reactivity to SSO.</p> </sec> <sec id="cod12468-sec-0003" sec-type="section"> <title>Methods</title> <p id="cod12468-para-0003">A retrospective analysis of data from the Information Network of Departments of Dermatology, 1998–2013, was performed.</p> </sec> <sec id="cod12468-sec-0004" sec-type="section"> <title>Results</title> <p id="cod12468-para-0004">The full FM I breakdown test including SSO was tested in 2952 patients. Of these, 154 (5.2%) had a positive patch test reaction to SSO 20% pet. and 2709 (91.8%) had a negative patch test reaction. Positive reactions to one or more of the single fragrances contained in the mix were significantly more common (82.5% versus 57.3%) in SSO‐positive patients, who also had more multiple reactions than FM I‐positive patients with negative SSO reactions (61.5% versus 21.3% patients with reactions to two or more fragrances).</p> </sec> <sec id="cod12468-sec-0005" sec-type="section"> <title>Conclusions</title> <p id="cod12468-para-0005">Our results indicate that reactivity to SSO markedly affects the outcome of patch testing with FM I and its single constituents. SSO must be an obligatory part of the full FM I breakdown test, and should ideally be included in the baseline series.</p> </sec> </abstract>