Sirolimus and everolimus in kidney transplantation. Issue 10 (October 2015)

• Record Type: Journal Article
• Authors: Moes, Dirk Jan A.R.; Guchelaar, Henk-Jan; de Fijter, Johan W.
• Is Part Of: Drug discovery today. Volume 20:Issue 10(2015)
• Page Start: 1243
• Page End: 1249
• Publication Date: 2015-10
• Subjects: Drugs -- Design -- Periodicals; Drugs -- Research -- Periodicals; 615.1
• DOI: 10.1016/j.drudis.2015.05.006
• Languages: English
• ISSNs: 1359-6446

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0005"> <list id="lis0005"> <list-item id="lsti0005"> <label></label> <p id="par0005">mTOR inhibitors have proven their efficacy and offer renal and antiviral benefits.</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010">Sirolimus and everolimus differ mainly in pharmacokinetic characteristics.</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0015">Novel approaches of monitoring mTOR inhibitors based therapy are under development.</p> </list-item> <list-item id="lsti0020"> <label></label> <p id="par0020">Pharmacogenetics of mTOR inhibitors should be expanded to pharmacodynamics.</p> </list-item> </list> </p> </sec> </abstract>