Back Cover: Discovery of a Single Monooxygenase that Catalyzes Carbamate Formation and Ring Contraction in the Biosynthesis of the Legonmycins (Angew. Chem. Int. Ed. 43/2015). Issue 43 (17th July 2015)

• Record Type: Journal Article
• Authors: Huang, Sheng; Tabudravu, Jioji; Elsayed, Somayah S.; Travert, Jeanne; Peace, Doe; Tong, Ming Him; Kyeremeh, Kwaku; Kelly, Sharon M.; Trembleau, Laurent; Ebel, Rainer; Jaspars, Marcel; Yu, Yi; Deng, Hai
• Is Part Of: Angewandte Chemie international edition. Volume 54:Issue 43(2015)
• Page Start: 12824
• Page End: 12824
• Publication Date: 2015-07-17
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201506192
• Languages: English
• ISSNs: 1433-7851

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>The multifunctional Baeyer–Villiger enzyme</bold> LgnC catalyzes the transformation of indolizidines into pyrrolizidines by carbamate formation, hydrolysis, decarboxylation‐driven ring contraction, and hydroxylation. In their Communication on <ext-link ext-link-type="doi" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink">page 12697 ff., </ext-link> H. Deng, Y. Yu et al. show that these are the crucial steps for the biosynthesis of the legonmycins, new bacterial pyrrolizidine alkaloids named after their association with Legon, Ghana.<graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgkg36x9xs" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></p> </abstract>