Structure, Biosynthesis, and Occurrence of Bacterial Pyrrolizidine Alkaloids. Issue 43 (25th August 2015)

• Record Type: Journal Article
• Authors: Schimming, Olivia; Challinor, Victoria L.; Tobias, Nicholas J.; Adihou, Hélène; Grün, Peter; Pöschel, Laura; Richter, Christian; Schwalbe, Harald; Bode, Helge B.
• Is Part Of: Angewandte Chemie international edition. Volume 54:Issue 43(2015)
• Page Start: 12702
• Page End: 12705
• Publication Date: 2015-08-25
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201504877
• Languages: English
• ISSNs: 1433-7851

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>Pyrrolizidine alkaloids (PAs) are widespread plant natural products with potent toxicity and bioactivity. Herein, the identification of bacterial PAs from entomopathogenic bacteria using differential analysis by 2D NMR spectroscopy (DANS) and mass spectrometry is described. Their biosynthesis was elucidated to involve a non‐ribosomal peptide synthetase. The occurrence of these biosynthesis gene clusters in Gram‐negative and Gram‐positive bacteria indicates an important biological function in bacteria.</p> </abstract>