Metabolic reprogramming of the tumour microenvironment. (25th August 2015)

• Record Type: Journal Article
• Authors: Xing, Yazhi; Zhao, Shimin; Zhou, Binhua P.; Mi, Jun
• Is Part Of: FEBS journal. Volume 282:Number 20(2015)
• Page Start: 3892
• Page End: 3898
• Publication Date: 2015-08-25
• Subjects: Biochemistry -- Periodicals; Molecular biology -- Periodicals; Pathology, Molecular -- Periodicals; 572
• DOI: 10.1111/febs.13402
• Languages: English
• ISSNs: 1742-464X

Abstract

<abstract abstract-type="main" id="febs13402-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <p>Tumour cells, stromal cells and the stroma comprise the tumour microenvironment. The metabolism of both tumour cells and several types of tumour stromal cells, such as cancer‐associated fibroblasts and tumour‐associated macrophages, is reprogrammed. Current studies have found that stromal cells promote tumour progression and metastasis, through not only the paracrine secretion of cytokines or chemokines, but also intermediate metabolites. Here, we summarize the latest insights into the mechanism of metabolic reprogramming in cancer cells, cancer‐associated fibroblasts and tumour‐associated macrophages, and their potential roles in tumour progression and metastasis.</p> </abstract>