Methyl-substitution of an iminohydantoin spiropiperidine β-secretase (BACE-1) inhibitor has a profound effect on its potency. Issue 21 (1st November 2015)

• Record Type: Journal Article
• Authors: Egbertson, Melissa; McGaughey, Georgia B.; Pitzenberger, Steven M.; Stauffer, Shaun R.; Coburn, Craig A.; Stachel, Shawn J.; Yang, Wenjin; Barrow, James C.; Neilson, Lou Anne; McWherter, Melody; Perlow, Debra; Fahr, Bruce; Munshi, Sanjeev; Allison, Timothy J.; Holloway, Katharine; Selnick, Harold G.; Yang, ZhiQiang; Swestock, John; Simon, Adam J.; Sankaranarayanan, Sethu; Colussi, Dennis; Tugusheva, Katherine; Lai, Ming-Tain; Pietrak, Beth; Haugabook, Shari; Jin, Lixia; Chen, I.-W.; Holahan, Marie; Stranieri-Michener, Maria; Cook, Jacquelynn J.; Vacca, Joseph; Graham, Samuel L.;
• Is Part Of: Bioorganic & medicinal chemistry letters. Volume 25:Issue 21(2015)
• Page Start: 4812
• Page End: 4819
• Publication Date: 2015-11-01
• Subjects: Bioorganic chemistry -- Periodicals; Pharmaceutical chemistry -- Periodicals; 572
• DOI: 10.1016/j.bmcl.2015.06.082
• Languages: English
• ISSNs: 0960-894X

Abstract

<abstract xml:lang="en" abstract-type="graphical" id="ab005"> <title id="st005">Graphical abstract</title> <sec> <p id="sp0005"> <fig id="f0055" position="anchor"> <graphic position="anchor" xlink:href="ark:/27927/pgkfznqhz1" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /> </fig> </p> </sec> </abstract>