Posttranscriptional regulation of T-type Ca2+ channel expression by interleukin-6 in prostate cancer cells. Issue 2 (December 2015)

• Record Type: Journal Article
• Authors: Weaver, Erika M.; Zamora, Francis J.; Hearne, Jennifer L.; Martin-Caraballo, Miguel
• Is Part Of: Cytokine. Volume 76:Issue 2(2015)
• Page Start: 309
• Page End: 320
• Publication Date: 2015-12
• Subjects: Cytokines -- Periodicals; 571.844
• DOI: 10.1016/j.cyto.2015.07.004
• Languages: English
• ISSNs: 1043-4666

Abstract

<abstract xml:lang="en" abstract-type="author-highlights" id="ab005"> <title id="st005">Highlights</title> <sec> <p id="sp0005"> <list id="l0005"> <list-item id="o0005"> <label></label> <p id="p0005">IL-6 evoked T-type Ca²⁺ channel expression was examined in prostate cancer cells.</p> </list-item> <list-item id="o0010"> <label></label> <p id="p0010">IL-6 has no effect on Ca_v3.2 mRNA, but increases Ca_v3.2 protein expression.</p> </list-item> <list-item id="o0015"> <label></label> <p id="p0015">IL-6 effect on the expression of functional channels in the membrane was minimal.</p> </list-item> <list-item id="o0020"> <label></label> <p id="p0020">IL-6 and forskolin promotes the functional expression of T-type Ca²⁺ channels.</p> </list-item> <list-item id="o0025"> <label></label> <p id="p0025">Functional T-type Ca²⁺ channels regulate morphological cell differentiation.</p> </list-item> </list> </p> </sec> </abstract>