Defective cytokine production early after multiple traumas: Modulation in severe sepsis. Issue 2 (December 2015) - Paraschos, Michael D.
Highlights There is a significant down-regulation of innate immune responses after severe injury. Over-production of interferon-gamma is linked with trauma-related multiple organ failure. Transition to severe sepsis is accompanied by over-production of tumour necrosis factor-alpha.