Borrelia-induced cytokine production is mediated by spleen tyrosine kinase (Syk) but is Dectin-1 and Dectin-2 independent. Issue 2 (December 2015)

• Record Type: Journal Article
• Authors: Oosting, Marije; Buffen, Kathrin; Cheng, Shih-Chin; Verschueren, Ineke C.; Koentgen, Frank; van de Veerdonk, Frank L.; Netea, Mihai G.; Joosten, Leo A.B.
• Is Part Of: Cytokine. Volume 76:Issue 2(2015)
• Page Start: 465
• Page End: 472
• Publication Date: 2015-12
• Subjects: Cytokines -- Periodicals; 571.844
• DOI: 10.1016/j.cyto.2015.08.005
• Languages: English
• ISSNs: 1043-4666

Abstract

<abstract xml:lang="en" abstract-type="author-highlights" id="ab005"> <title id="st005">Highlights</title> <sec> <p id="sp0005"> <list id="l0005"> <list-item id="o0005"> <label></label> <p id="p0005">Blocking Dectin does not lead to abrogated cytokine responses induced by <italic>Borrelia.</italic></p> </list-item> <list-item id="o0010"> <label></label> <p id="p0010">SNP Tyr238X in Dectin-1 does not influence <italic>Borrelia-</italic>induced cytokines.</p> </list-item> <list-item id="o0015"> <label></label> <p id="p0015"> <italic>Borrelia-</italic>induced cytokines are equal between wild-type and Dectin-1-/- mice.</p> </list-item> <list-item id="o0020"> <label></label> <p id="p0020">Dectin-2 is partly involved in murine <italic>Borrelia</italic>-induced joint inflammation.</p> </list-item> <list-item id="o0025"> <label></label> <p id="p0025"> <italic>Borrelia-</italic>induced cytokines are dependent on Syk signaling.</p> </list-item> </list> </p> </sec> </abstract>