Transcriptional regulation of the VEGF gene in dependence of individual genomic variations. Issue 2 (December 2015)

• Record Type: Journal Article
• Authors: Metzger, Carmen S.; Koutsimpelas, Dimitrios; Brieger, Juergen
• Is Part Of: Cytokine. Volume 76:Issue 2(2015)
• Page Start: 519
• Page End: 526
• Publication Date: 2015-12
• Subjects: Cytokines -- Periodicals; 571.844
• DOI: 10.1016/j.cyto.2015.07.015
• Languages: English
• ISSNs: 1043-4666

Abstract

<abstract xml:lang="en" abstract-type="author-highlights" id="ab005"> <title id="st005">Highlights</title> <sec> <p id="sp0005"> <list id="l0005"> <list-item id="o0005"> <label></label> <p id="p0005">VEGF-overexpression is connected to advanced stage and poor survival in cancer.</p> </list-item> <list-item id="o0010"> <label></label> <p id="p0010">We reviewed a potential influence of VEGF-SNPs on transcriptional regulation.</p> </list-item> <list-item id="o0015"> <label></label> <p id="p0015">Decreasing binding specificity was observed for MZF1 in presence of +405 C-allele.</p> </list-item> <list-item id="o0020"> <label></label> <p id="p0020">SNP-2578-linked insertion increased number of potential TFB sites.</p> </list-item> <list-item id="o0025"> <label></label> <p id="p0025">Association of SNPs and TFB could be an essential part of VEGF-regulation.</p> </list-item> </list> </p> </sec> </abstract>