Genome-derived cytosolic DNA contributes to type I interferon expression and immunogenicity of B-cell lymphoma cells. Issue 2 (December 2015)

• Record Type: Journal Article
• Authors: Shen, Yu J.; Ho, Samantha S.W.; Tan, Nikki Y.; Koo, Christine Xing'Er; Khatoo, Muznah; Cheung, Florence S.G.; Gasser, Stephan
• Is Part Of: Cytokine. Volume 76:Issue 2(2015)
• Page Start: 581
• Page End: 582
• Publication Date: 2015-12
• Subjects: Cytokines -- Periodicals; 571.844
• DOI: 10.1016/j.cyto.2015.05.024
• Languages: English
• ISSNs: 1043-4666

Abstract

<abstract xml:lang="en" abstract-type="author-highlights" id="ab005"> <title id="st005">Highlights</title> <sec> <p id="sp0005"> <list id="l0005"> <list-item id="o0005"> <label></label> <p id="p0005">Genome-derived ssDNA, dsDNA and DNA:RNA hybrids are present in the cytosol of tumor cells.</p> </list-item> <list-item id="o0010"> <label></label> <p id="p0010">Cytosolic DNA can potentially form non-B DNA structures.</p> </list-item> <list-item id="o0015"> <label></label> <p id="p0015">Cytosolic DNA contributes to type I interferon-dependent immune rejection of B-cell lymphoma.</p> </list-item> </list> </p> </sec> </abstract>