NRF2/miR-140 signaling confers radioprotection to human lung fibroblasts. Issue 1 (1st December 2015)

• Record Type: Journal Article
• Authors: Duru, Nadire; Gernapudi, Ramkishore; Zhang, Yongshu; Yao, Yuan; Lo, Pang-Kuo; Wolfson, Benjamin; Zhou, Qun
• Is Part Of: Cancer letters. Volume 369:Issue 1(2016)
• Page Start: 184
• Page End: 191
• Publication Date: 2015-12-01
• Subjects: Cancer -- Periodicals; Neoplasms -- Periodicals; Cancer -- Périodiques; Electronic journals; 616.994
• DOI: 10.1016/j.canlet.2015.08.011
• Languages: English
• ISSNs: 0304-3835

Abstract

<abstract abstract-type="author-highlights" id="ab0010"> <title id="st0010">Highlights</title> <sec> <p id="sp0010"> <list id="ulist0010"> <list-item id="u0010"> <label></label> <p id="p0010">Ionizing radiation induces BRCA1-dependent activation of NRF2 in human lung fibroblasts.</p> </list-item> <list-item id="u0015"> <label></label> <p id="p0015">BRCA1 activates NRF2 through the negative regulation of KEAP1.</p> </list-item> <list-item id="u0020"> <label></label> <p id="p0020">miR-140 is a novel target gene for NRF2 in human lung fibroblasts.</p> </list-item> <list-item id="u0025"> <label></label> <p id="p0025">BRCA1/NRF2/miR-140 signaling axis confers radioprotection to human lung fibroblasts.</p> </list-item> </list> </p> </sec> </abstract>