Suppression of the GTPase-activating protein RGS10 increases Rheb-GTP and mTOR signaling in ovarian cancer cells. Issue 1 (1st December 2015)

• Record Type: Journal Article
• Authors: Altman, Molly K.; Alshamrani, Ali A.; Jia, Wei; Nguyen, Ha T.; Fambrough, Jada M.; Tran, Sterling K.; Patel, Mihir B.; Hoseinzadeh, Pooya; Beedle, Aaron M.; Murph, Mandi M.
• Is Part Of: Cancer letters. Volume 369:Issue 1(2016)
• Page Start: 175
• Page End: 183
• Publication Date: 2015-12-01
• Subjects: Cancer -- Periodicals; Neoplasms -- Periodicals; Cancer -- Périodiques; Electronic journals; 616.994
• DOI: 10.1016/j.canlet.2015.08.012
• Languages: English
• ISSNs: 0304-3835

Abstract

<abstract abstract-type="author-highlights" id="ab0010"> <title id="st0010">Highlights</title> <sec> <p id="sp0010"> <list id="ulist0010"> <list-item id="u0010"> <label></label> <p id="p0010">RGS10 suppression triggers phosphorylation of mTOR, 4E-BP1, p70S6K and rProtein-S6.</p> </list-item> <list-item id="u0015"> <label></label> <p id="p0015">Rheb-GTP is increased in ovarian cancer cells after RGS10 suppression.</p> </list-item> <list-item id="u0020"> <label></label> <p id="p0020">Suppression of RGS10 increases cell proliferation in the presence of chemotherapy.</p> </list-item> <list-item id="u0025"> <label></label> <p id="p0025">Effects of RGS10 suppression occur in serum-free conditions with low nutrients.</p> </list-item> </list> </p> </sec> </abstract>