Epigenetic silencing of Kruppel like factor-3 increases expression of pro-metastatic miR-182. Issue 1 (1st December 2015)

• Record Type: Journal Article
• Authors: Sachdeva, Mohit; Dodd, Rebecca D.; Huang, Zhiqing; Grenier, Carole; Ma, Yan; Lev, Dina C.; Cardona, Diana M.; Murphy, Susan K.; Kirsch, David G.
• Is Part Of: Cancer letters. Volume 369:Issue 1(2016)
• Page Start: 202
• Page End: 211
• Publication Date: 2015-12-01
• Subjects: Cancer -- Periodicals; Neoplasms -- Periodicals; Cancer -- Périodiques; Electronic journals; 616.994
• DOI: 10.1016/j.canlet.2015.08.016
• Languages: English
• ISSNs: 0304-3835

Abstract

<abstract abstract-type="author-highlights" id="ab0010"> <title id="st0010">Highlights</title> <sec> <p id="sp0010"> <list id="ulist0010"> <list-item id="u0010"> <label></label> <p id="p0010">Klf-3 is a novel transcriptional repressor of pro-metastatic miR-182 in sarcomas.</p> </list-item> <list-item id="u0015"> <label></label> <p id="p0015">Klf-3 suppresses a myogenic transcription factor MyoD1.</p> </list-item> <list-item id="u0020"> <label></label> <p id="p0020">Klf-3 is epigenetically silenced by DNA hypermethylation.</p> </list-item> <list-item id="u0025"> <label></label> <p id="p0025">Demethylating agents could potentially be used to modulate miR-182 levels as a therapeutic strategy.</p> </list-item> </list> </p> </sec> </abstract>