Enhanced anti-colon cancer immune responses with modified eEF2-derived peptides. Issue 1 (1st December 2015)

• Record Type: Journal Article
• Authors: Sun, Weihong; Wei, Xiaofang; Niu, Airong; Ma, Xuezhen; Li, Jian Jian; Gao, Daiqing
• Is Part Of: Cancer letters. Volume 369:Issue 1(2016)
• Page Start: 112
• Page End: 123
• Publication Date: 2015-12-01
• Subjects: Cancer -- Periodicals; Neoplasms -- Periodicals; Cancer -- Périodiques; Electronic journals; 616.994
• DOI: 10.1016/j.canlet.2015.08.002
• Languages: English
• ISSNs: 0304-3835

Abstract

<abstract abstract-type="author-highlights" id="ab0010"> <title id="st0010">Highlights</title> <sec> <p id="sp0010"> <list id="ulist0010"> <list-item id="u0010"> <label></label> <p id="p0010">The peptide from eEF2, P739–747 (RLMEPIYLV), elicits CTL responses <italic>in vivo</italic> and <italic>in vitro</italic>.</p> </list-item> <list-item id="u0015"> <label></label> <p id="p0015">The modifications in P739–747 sequence improve the immunogenicity against eEF2.</p> </list-item> <list-item id="u0020"> <label></label> <p id="p0020">Analog peptides with HLA-A*0201 anchor induces CTLs with cross-reactive to the native peptide.</p> </list-item> <list-item id="u0025"> <label></label> <p id="p0025">The modified analogs inhibit tumor growth more efficiently than the native peptides.</p> </list-item> </list> </p> </sec> </abstract>