Plasma iron, C‐reactive protein, albumin, and plasma fibrinogen concentrations in dogs with systemic inflammatory response syndrome. (14th July 2015)

• Record Type: Journal Article
• Authors: Torrente, Carlos; Manzanilla, Edgar G.; Bosch, Luis; Fresno, Laura; Rivera del Alamo, Montserrat; Andaluz, Anna; Saco, Yolanda; Ruiz de Gopegui, Rafael
• Is Part Of: Journal of veterinary emergency and critical care. Volume 25:Number 5(2015:Sep./Oct.)
• Page Start: 611
• Page End: 619
• Publication Date: 2015-07-14
• Subjects: Veterinary emergencies -- Periodicals; Veterinary critical care -- Periodicals; 636.089
• DOI: 10.1111/vec.12340
• Languages: English
• ISSNs: 1479-3261

Abstract

<abstract abstract-type="main"> <title>Abstract</title> <sec id="vec12340-sec-0010" sec-type="section"> <title>Objective</title> <p>To investigate the diagnostic and prognostic value over time of plasma iron compared with the inflammatory markers albumin, C‐reactive protein (CRP), and fibrinogen in dogs with systemic inflammatory response syndrome (SIRS).</p> </sec> <sec id="vec12340-sec-0020" sec-type="section"> <title>Design</title> <p>Prospective observational study of sequentially enrolled dogs.</p> </sec> <sec id="vec12340-sec-0030" sec-type="section"> <title>Setting</title> <p>ICU of a veterinary teaching hospital.</p> </sec> <sec id="vec12340-sec-0040" sec-type="section"> <title>Animals</title> <p>One hundred and sixteen client‐owned dogs: 54 dogs with SIRS or sepsis, 42 with focal inflammation, and 20 clinically healthy dogs.</p> </sec> <sec id="vec12340-sec-0050" sec-type="section"> <title>Measurements and Main Results</title> <p>Blood samples were obtained on admission in all study groups, and then on alternate days until discharge or death in both inflammation groups. On admission, dogs with SIRS had significantly lower plasma iron (65 ± 5.8 μg/dL, <italic>P</italic> = 0.001) concentrations than dogs with focal inflammation (89.5 ± 6.2 μg/dL, <italic>P</italic> = 0.001). Plasma iron, albumin, and CRP effectively discriminated the SIRS/sepsis group from those presenting with focal inflammation with areas under the curve for the receiver operating curves of 0.679, 0.834, and 0.704, respectively.</p> <p>The admission values for these variables did not discriminate survivors from nonsurvivors within the SIRS/sepsis group. However, the magnitude of increase in iron concentration and the decrease in CRP concentration from admission to hospital discharge was higher in survivors than in nonsurvivors within the SIRS/septic group (22.8 vs. 2.51 μg/dL, respectively, <italic>P</italic> = 0.021 for iron; −67.1 vs. −4.1 mg/L, respectively, <italic>P</italic> = 0.002 for CRP), resulting in iron and CRP concentrations at hospital discharge for survivors similar to those in the focal inflammation group.</p> </sec> <sec id="vec12340-sec-0060" sec-type="section"> <title>Conclusion</title> <p>Hypoferremia is a sensitive marker of systemic inflammation in dogs. In this study, the increase in iron concentrations during the hospitalization period of SIRS/septic dogs was associated with a better prognosis, suggesting that plasma iron in combination with CRP and albumin concentrations might be used to monitor dogs with inflammatory disease processes.</p> </sec> </abstract>