Combination therapy for multidrug‐resistant cytomegalovirus disease. Issue 5 (3rd October 2015)

• Record Type: Journal Article
• Authors: Stuehler, C.; Stüssi, G.; Halter, J.; Nowakowska, J.; Schibli, A.; Battegay, M.; Dirks, J.; Passweg, J.; Heim, D.; Rovo, A.; Kalberer, C.; Bucher, C.; Weisser, M.; Dumoulin, A.; Hirsch, H.H.; Khanna, N.
• Is Part Of: Transplant infectious disease. Volume 17:Issue 5(2016)
• Page Start: 751
• Page End: 755
• Publication Date: 2015-10-03
• Subjects: Transplantation of organs, tissues, etc -- Complications -- Periodicals; Communicable diseases -- Periodicals; Infection -- Periodicals; 617.01
• DOI: 10.1111/tid.12435
• Languages: English
• ISSNs: 1398-2273

Abstract

<abstract abstract-type="main" id="tid12435-abs-0001"> <title>Abstract</title> <p>Multidrug‐resistant (MDR) cytomegalovirus (CMV) emerged after transient responses to ganciclovir, foscarnet, and cidofovir in a CMV‐seropositive recipient who underwent allogeneic hematopoietic stem cell transplantation from a CMV‐seronegative donor. Experimental treatments using leflunomide and artesunate failed. Re‐transplantation from a CMV‐seropositive donor supported by adoptive transfer of pp65‐specific T cells and maribavir was followed by lasting suppression. This case illustrates that successful MDR CMV therapy may require individualized multidisciplinary approaches.</p> </abstract>