Detection of human cytomegalovirus (CMV) DNA in feces has limited value in predicting CMV enteritis in patients with intestinal graft‐versus‐host disease after allogeneic stem cell transplantation. Issue 5 (14th August 2015)

• Record Type: Journal Article
• Authors: Sun, Y.‐Q.; Xu, L.‐P.; Han, T.‐T.; Zhang, X.‐H.; Wang, Y.; Han, W.; Wang, F.‐R.; Wang, J.‐Z.; Chen, H.; Chen, Y.‐H.; Yan, C.‐H.; Chen, Y.; Liu, K.‐Y.; Huang, X.‐J.
• Is Part Of: Transplant infectious disease. Volume 17:Issue 5(2016)
• Page Start: 655
• Page End: 661
• Publication Date: 2015-08-14
• Subjects: Transplantation of organs, tissues, etc -- Complications -- Periodicals; Communicable diseases -- Periodicals; Infection -- Periodicals; 617.01
• DOI: 10.1111/tid.12420
• Languages: English
• ISSNs: 1398-2273

Abstract

<abstract abstract-type="main" id="tid12420-abs-0001"> <title>Abstract</title> <sec id="tid12420-sec-0001" sec-type="section"> <title>Background</title> <p>Cytomegalovirus (CMV) enteritis after allogeneic hematopoietic stem cell transplantation (allo‐HSCT) is difficult to diagnose. We aimed to evaluate the sensitivity and specificity of the detection of CMV DNA in feces for predicting CMV enteritis.</p> </sec> <sec id="tid12420-sec-0002" sec-type="section"> <title>Methods</title> <p>HSCT patients with intestinal graft‐versus‐host disease (GVHD) were enrolled if they met the following criteria: (i) underwent a colonoscopy and (ii) peripheral blood and feces specimens were available for CMV DNA detection within 24 h of colonoscopy. The colonoscopy histology was used as the gold standard for diagnosing CMV enteritis.</p> </sec> <sec id="tid12420-sec-0003" sec-type="section"> <title>Results</title> <p>Fifty‐six patients underwent 58 colonoscopy examinations, and 7 were diagnosed as having CMV enteritis. Within 24 h of colonoscopy, 9 patients had detectable CMV in the feces and 19 patients had detectable CMV in the plasma, respectively. In the 7 patients with CMV enteritis, only 2 had detectable CMV in the stool, resulting in a sensitivity of 28.6%. In the 51 patients without CMV enteritis, 44 had no detectable CMV in the stool, with a specificity of 86.3%.</p> </sec> <sec id="tid12420-sec-0004" sec-type="section"> <title>Conclusion</title> <p>We concluded that CMV detection in the feces was not a good predictor of CMV enteritis in patients with intestinal GVHD after allo‐HSCT.</p> </sec> </abstract>