Association between IL28B polymorphism, TNFα and biomarkers of insulin resistance in chronic hepatitis C‐related insulin resistance. Issue 11 (26th March 2015)

• Record Type: Journal Article
• Authors: Lemoine, M.; Chevaliez, S.; Bastard, J. P.; Fartoux, L.; Chazouillères, O.; Capeau, J.; Pawlotsky, J. M.; Serfaty, L.
• Is Part Of: Journal of viral hepatitis. Volume 22:Issue 11(2015)
• Page Start: 890
• Page End: 896
• Publication Date: 2015-03-26
• Subjects: Hepatitis, Viral -- Periodicals; Hepatitis, Viral, Animal; Hepatitis, Viral, Human; 616.3623
• DOI: 10.1111/jvh.12408
• Languages: English
• ISSNs: 1352-0504

Abstract

<abstract abstract-type="main" id="jvh12408-abs-0001"> <title>Summary</title> <p>TNF<italic>α</italic> has been shown to play a role in hepatitis C virus (HCV)‐induced insulin resistance (IR). Polymorphism of the <italic>IL28B</italic> gene that encodes IFN‐lambda 3 may be associated with IR through modulation of TNF<italic>α</italic>. The aim of this study was to investigate the relationship between <italic>IL28B</italic> rs12979860 genotype, the level of TNF<italic>α</italic> activation and the degree of IR in patients with chronic hepatitis C. One hundred and thirty‐three nondiabetic genotype 1 HCV‐infected patients with biopsy proven noncirrhotic hepatitis C were investigated for IR (using HOMA index), <italic>IL28B</italic> rs12979860 genotype and fasting circulating levels of soluble receptor 1 of TNF<italic>α</italic> (sTNFR1) and adipokines: leptin, adiponectin and IL‐6. The HOMA‐IR was positively correlated with serum levels of leptin (<italic>r</italic> = 0.35, <italic>P</italic> < 0.0001) and sTNFR1 (<italic>r</italic> = 0.35, <italic>P</italic> < 0.0001) but not with IL‐6 or adiponectin. <italic>IL28B</italic> rs12979860 CC genotype was observed in 35% patients. Genotype CC and nongenotype CC patients were similar in terms of HOMA‐IR (means 1.6 ± 0.9 <italic>vs</italic> 1.7 ± 1.4) and had similar circulating levels of sTNFR1 and adipokines. Independent factors associated with IR were ferritin (OR = 1.002, <italic>P</italic> = 0.02), leptin (OR = 1.06, <italic>P</italic> = 0.02) and sTNFR1 (OR = 7.9, <italic>P</italic> = 0.04). This study suggests that in nondiabetic, noncirrhotic, HCV genotype 1‐infected patients, there is no relationship between <italic>IL28B</italic> rs12979860 genotype and HOMA‐IR or sTNFR1 level. HCV‐related IR may be mediated through TNF<italic>α</italic> independent of <italic>IL28B</italic> genotype.</p> </abstract>