Octreotide protects ovary against ischemia–reperfusion injury in rats: Evaluation of histological and biochemical parameters. Issue 10 (30th July 2015)

• Record Type: Journal Article
• Authors: Yildirim, Nuri; Yigitturk, Gurkan; Sahingoz Yildirim, Alkim Gulsah; Akdemir, Ali; İlgen, Orkun; Yeniel, Ozgur; Ergenoglu, Mete; Erbas, Oytun
• Is Part Of: Journal of obstetrics and gynaecology research. Volume 41:Issue 10(2015:Oct.)
• Page Start: 1591
• Page End: 1597
• Publication Date: 2015-07-30
• Subjects: Gynecology -- Periodicals; Obstetrics -- Periodicals; 618.1005
• DOI: 10.1111/jog.12770
• Languages: English
• ISSNs: 1341-8076

Abstract

<abstract abstract-type="main"> <title>Abstract</title> <sec id="jog12770-sec-0001" sec-type="section"> <title>Aim</title> <p>This study investigated the efficacy of octreotide for prevention of ischemia–reperfusion injury in rat ovary.</p> </sec> <sec id="jog12770-sec-0002" sec-type="section"> <title>Methods</title> <p>Thirty‐two adult female rats were included. Rats were divided into five groups: in the sham group, the abdominal wall was only opened and closed; in the torsion group, ischemia was induced for 3 h using a torsion model involving atraumatic vascular clips; in the torsion/octreotide group, rats were given 100 µg/kg i.p. octreotide 30 min before torsion was induced; in the torsion/detorsion group, rats underwent 3 h ischemia–3 h reperfusion; in the torsion/detorsion/octreotide group, rats underwent 3 h ischemia followed by 100 µg/kg octreotide i.p. 30 min prior to 3 h reperfusion. Ovarian tissue damage was scored on histopathology. Ovarian tissue malondialdehyde and plasma pentraxin 3 were measured biochemically.</p> </sec> <sec id="jog12770-sec-0003" sec-type="section"> <title>Results</title> <p>In comparison with the sham group, both the torsion and torsion/detorsion groups had significantly higher scores for follicular degeneration, vascular congestion, edema, hemorrhage and leukocyte infiltration. Octreotide significantly decreased these scores in both groups. Ovarian malondialdehyde and plasma pentraxin 3 were significantly higher both in the torsion and torsion/detorsion groups compared with the sham group. Octreotide also decreased these levels significantly both in the torsion/octreotide and torsion/detorsion/octreotide groups.</p> </sec> <sec id="jog12770-sec-0004" sec-type="section"> <title>Conclusion</title> <p>Octreotide ameliorated the potential side‐effects of ovarian ischemia–reperfusion injury in a rat model.</p> </sec> </abstract>