Headless Myo10 is a regulator of microtubule stability during neuronal development. (3rd August 2015)

• Record Type: Journal Article
• Authors: Yu, Huali; Sun, Dong; Wang, Nannan; Wang, Min; Lan, Yongsheng; Fan, Wenqiang; Zhao, Yang; Guo, Weixiang; Zhu, Xiaojuan
• Is Part Of: Journal of neurochemistry. Volume 135:Number 2(2015:Oct.)
• Page Start: 261
• Page End: 273
• Publication Date: 2015-08-03
• Subjects: Neurochemistry -- Periodicals; 616.8042
• DOI: 10.1111/jnc.13238
• Languages: English
• ISSNs: 0022-3042

Abstract

<abstract abstract-type="main" id="jnc13238-abs-0001"> <title>Abstract</title> <sec id="jnc13238-sec-1001" sec-type="section"> <p>Stabilized microtubules are required for neuronal morphogenesis and migration. However, the underlying mechanism is not fully understood. In this study, we demonstrate that myosin X (Myo10), which is composed of full‐length myosin X (fMyo10) and headless myosin X (hMyo10), is important for axon development. fMyo10 is involved in axon elongation, whereas hMyo10 is critical for Tau‐1 positive axon formation through stabilizing microtubules. Furthermore, <italic>in vivo</italic> studies reveal that hMyo10‐mediated microtubule stability has a profound effect on both neuronal migration and dendritic arborization in the mammalian cerebral cortex. Taken together, our findings suggest that hMyo10 is involved in neuronal development both <italic>in vitro</italic> and <italic>in vivo</italic> by regulating microtubule stability.</p> </sec> <sec id="jnc13238-sec-1101" sec-type="section"> <p> <boxed-text content-type="graphic" id="jnc13238-blkfxd-1001" position="anchor" orientation="portrait"> <graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgkfp0f4kj" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /> </boxed-text> In this study, we demonstrate that headless myosin X (hMyo10) is involved in microtubule stability regulation, which is important for neuronal morphogenesis and migration. <italic>In vitro</italic> studies reveal that hMyo10 regulates Tau‐1 positive axon formation through stabilizing microtubules. Furthermore, <italic>in vivo</italic> studies reveal that hMyo10‐mediated microtubule stability has a profound effect on radial cortical neuronal migration and apical dendritic arborization. </p> </sec> </abstract>