Acute‐phase response following full‐mouth versus quadrant non‐surgical periodontal treatment: A randomized clinical trial2. (1st October 2015)

• Record Type: Journal Article
• Authors: Graziani, Filippo; Cei, Silvia; Orlandi, Marco; Gennai, Stefano; Gabriele, Mario; Filice, Natalia; Nisi, Marco; D'Aiuto, Francesco
• Is Part Of: Journal of clinical periodontology. Volume 42:Number 9(2015:Sep.)
• Page Start: 843
• Page End: 852
• Publication Date: 2015-10-01
• Subjects: Periodontics -- Periodicals; 617.6
• DOI: 10.1111/jcpe.12451
• Languages: English
• ISSNs: 0303-6979

Abstract

<abstract abstract-type="main" id="jcpe12451-abs-0001"> <title>Abstract</title> <sec id="jcpe12451-sec-0001" sec-type="section"> <title>Aim</title> <p>A moderate acute‐phase response occurs 24‐h following full‐mouth non‐surgical treatment (FM‐SRP). The aim of this study was to compare acute‐phase (24‐h) and medium‐term (3 months) inflammation after quadrant scaling (Q‐SRP) <italic>versus</italic> FM‐SRP.</p> </sec> <sec id="jcpe12451-sec-0002" sec-type="section"> <title>Material & Methods</title> <p>Thirty‐eight periodontitis‐affected subjects were randomly allocated to FM‐SRP or Q‐SRP after a baseline visit. Periodontal and anthropometric parameters were collected at baseline and 3 months. Serum samples were drawn at baseline, 1, 7, and 90 days after treatment. High‐sensitivity assays of inflammation and endothelial assays were performed.</p> </sec> <sec id="jcpe12451-sec-0003" sec-type="section"> <title>Results</title> <p>FM‐SRP produced a greater acute‐phase response after 24 h [threefold increase in C‐reactive protein (CRP), twofold increase in interleukin (IL‐6), and a slight increase in tumour necrosis factor]. No differences in systemic biomarkers were noted between groups at any later follow‐ups. Both periodontal treatments produced a comparable improvement in clinical periodontal parameters with no between‐group differences. Treatment time was positively associated with the relative 24‐h increase in CRP (<italic>R</italic> = 0.5, <italic>p</italic> < 0.001) and IL‐6 (<italic>R</italic> = 0.5, <italic>p</italic> = 0.002), while the number of deeper (>6 mm) pockets predicted only the relative increase in IL‐6 (<italic>R</italic> = 0.4, <italic>p</italic> < 0.05).</p> </sec> <sec id="jcpe12451-sec-0004" sec-type="section"> <title>Conclusions</title> <p>FM‐SRP triggers a moderate acute‐phase response of 24 h duration compared to Q‐SRP. Further research is needed to assess the eventual impact of such findings on the risk of vascular events is advocated. (ClinicalTrials.gov NCT01857804).</p> </sec> </abstract>