Country of birth modifies the association of fatty liver index with insulin action in Middle Eastern immigrants to Sweden. Issue 1 (October 2015)

• Record Type: Journal Article
• Authors: Bennet, Louise; Groop, Leif; Franks, Paul W.
• Is Part Of: Diabetes research and clinical practice. Volume 110:Issue 1(2015)
• Page Start: 66
• Page End: 74
• Publication Date: 2015-10
• Subjects: Diabetes -- Periodicals; Diabetes Mellitus -- Periodicals; 616.462
• DOI: 10.1016/j.diabres.2015.07.011
• Languages: English
• ISSNs: 0168-8227

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0005"> <list id="lis0005"> <list-item id="lsti0005"> <label></label> <p id="par0005">Non-alcohol fatty liver disease (NAFLD) is a strong risk factor for type 2 diabetes. The prevalence of NAFLD varies across populations of different ethnic backgrounds but the prevalence in Middle Eastern populations, which are at high risk of type 2 diabetes, is largely unknown.</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010">We investigated fatty liver index (FLI), an estimate of NAFLD. Further we calculated the odds of NAFLD (FLI ≥ 70) given country of origin and also studied associations between insulin sensitivity index (ISI) and FLI.</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0015">Furthermore, high FLI and Iraqi origin were independently associated with impaired insulin action irrespective of traditional risk factors such as physical inactivity, abdominal obesity and type 2 diabetes.</p> </list-item> <list-item id="lsti0020"> <label></label> <p id="par0020">The finding that country of birth modifies the relationship of FLI with ISI, suggests a stronger effect of fatty liver on insulin action in Iraqis than in Swedes, and opens a possible effect of fatty liver as a cause of impaired insulin action and increased risk of type 2 diabetes in this population that to our knowledge has not been reported before.</p> </list-item> </list> </p> </sec> </abstract>