A novel retinal biomarker for Parkinson's disease: Quantifying the foveal pit with optical coherence tomography. Issue 12 (4th September 2015)

• Record Type: Journal Article
• Authors: Slotnick, Samantha; Ding, Yin; Glazman, Sofya; Durbin, Mary; Miri, Shahnaz; Selesnick, Ivan; Sherman, Jerome; Bodis‐Wollner, Ivan
• Is Part Of: Movement disorders. Volume 30:Issue 12(2015)
• Page Start: 1692
• Page End: 1695
• Publication Date: 2015-09-04
• Subjects: Movement disorders -- Periodicals; 610
• DOI: 10.1002/mds.26411
• Languages: English
• ISSNs: 0885-3185

Abstract

<abstract abstract-type="main"> <title>Abstract</title> <sec id="mds26411-sec-0001" sec-type="section"> <title>Background</title> <p>Optical coherence tomography offers a potential biomarker tool in Parkinson's disease (PD). A mathematical model quantifying symmetry, breadth, and depth of the fovea was applied.</p> </sec> <sec id="mds26411-sec-0002" sec-type="section"> <title>Methods</title> <p>Nintey‐six subjects (72 PD and 24 healthy controls) were included in the study. Macular scans of each eye were obtained on two different optical coherence tomography devices: Cirrus and RTVue.</p> </sec> <sec id="mds26411-sec-0003" sec-type="section"> <title>Results</title> <p>The variables corresponding to the cardinal gradients of the fovea were the most sensitive indicators of PD for both devices. Principal component analysis distinguished 65% of PD patients from controls on Cirrus, 57% on RTVue.</p> </sec> <sec id="mds26411-sec-0004" sec-type="section"> <title>Conclusion</title> <p>Parkinson's disease shallows the superior/inferior and to a lesser degree nasal‐temporal foveal slope. The symmetry, breadth, and depth model fits optical coherence tomography data derived from two different devices, and it is proposed as a diagnostic tool in PD. © 2015 International Parkinson and Movement Disorder Society</p> </sec> </abstract>