Exercise improves cognition in Parkinson's disease: The PRET‐PD randomized, clinical trial. Issue 12 (6th July 2015)

• Record Type: Journal Article
• Authors: David, Fabian J.; Robichaud, Julie A.; Leurgans, Sue E.; Poon, Cynthia; Kohrt, Wendy M.; Goldman, Jennifer G.; Comella, Cynthia L.; Vaillancourt, David E.; Corcos, Daniel M.
• Is Part Of: Movement disorders. Volume 30:Issue 12(2015)
• Page Start: 1657
• Page End: 1663
• Publication Date: 2015-07-06
• Subjects: Movement disorders -- Periodicals; 610
• DOI: 10.1002/mds.26291
• Languages: English
• ISSNs: 0885-3185

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="mds26291-sec-0001" sec-type="section"> <title>Background</title> <p>This article reports on the findings of the effect of two structured exercise interventions on secondary cognitive outcomes that were gathered as part of the Progressive Resistance Exercise Training in Parkinson's disease (PD) randomized, controlled trial.</p> </sec> <sec id="mds26291-sec-0002" sec-type="section"> <title>Methods</title> <p>This study was a prospective, parallel‐group, single‐center trial. Fifty‐one nondemented patients with mild‐to‐moderate PD were randomly assigned either to modified Fitness Counts (mFC) or to Progressive Resistance Exercise Training (PRET) and were followed for 24 months. Cognitive outcomes were the Digit Span, Stroop, and Brief Test of Attention (BTA).</p> </sec> <sec id="mds26291-sec-0003" sec-type="section"> <title>Results</title> <p>Eighteen patients in mFC and 20 patients in PRET completed the trial. At 12 and at 24 months, no differences between groups were observed. At 12 months, relative to baseline, mFC improved on the Digit Span (estimated change: 0.3; interquartile range: 0, 0.7; <italic>P</italic> = 0.04) and Stroop (0.3; 0, 0.6; <italic>P</italic> = 0.04), and PRET improved only on the Digit Span (0.7; 0.3, 1; <italic>P</italic> < 0.01). At 24 months, relative to baseline, mFC improved on the Digit Span (0.7; 0.3, 1.7; <italic>P</italic> < 0.01) and Stroop (0.3; 0.1, 0.5; <italic>P</italic> = 0.03), whereas PRET improved on the Digit Span (0.5; 0.2, 0.8; <italic>P</italic> < 0.01), Stroop (0.2; −0.1, 0.6; <italic>P</italic> = 0.048), and BTA (0.3; 0, 0.8; <italic>P</italic> = 0.048). No neurological or cognitive adverse events were observed.</p> </sec> <sec id="mds26291-sec-0004" sec-type="section"> <title>Conclusions</title> <p>This study provides class IV level of evidence that 24 months of PRET or mFC may improve attention and working memory in nondemented patients with mild‐to‐moderate Parkinson's disease. © 2015 International Parkinson and Movement Disorder Society</p> </sec> </abstract>