A Remarkably Simple Class of Imidazolium‐Based Lipids and Their Biological Properties. Issue 43 (2nd September 2015)

• Record Type: Journal Article
• Authors: Wang, Da; Richter, Christian; Rühling, Andreas; Drücker, Patrick; Siegmund, Daniel; Metzler‐Nolte, Nils; Glorius, Frank; Galla, Hans‐Joachim
• Is Part Of: Chemistry. Volume 21:Issue 43(2015)
• Page Start: 15123
• Page End: 15126
• Publication Date: 2015-09-02
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/chem.201502333
• Languages: English
• ISSNs: 0947-6539

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>A series of imidazolium salts bearing two alkyl chains in the backbone of the imidazolium core were synthesized, resembling the structure of lipids. Their antibacterial activity and cytotoxicity were evaluated using Gram‐positive and Gram‐negative bacteria and eukaryotic cell lines including tumor cells. It is shown that the length of alkyl chains in the backbone is vital for the antibiofilm activities of these lipid‐mimicking components. In addition to their biological activity, their surface activity and their membrane interactions are shown by film balance and quartz crystal microbalance (QCM) measurements. The structure–activity relationship indicates that the distinctive chemical structure contributes considerably to the biological activities of this novel class of lipids.</p> </abstract>