Effects of Lonicera japonica Thunb. on Type 2 Diabetes via PPAR‐γ Activation in Rats. (14th July 2015)

• Record Type: Journal Article
• Authors: Han, Jae Min; Kim, Mi Hye; Choi, You Yeon; Lee, Haesu; Hong, Jongki; Yang, Woong Mo
• Is Part Of: Phytotherapy research. Volume 29:Number 10(2015:Oct.)
• Page Start: 1616
• Page End: 1621
• Publication Date: 2015-07-14
• Subjects: Materia medica, Vegetable -- Periodicals; Botany, Medical -- Periodicals; Medicinal plants -- Periodicals; Plant Extracts -- therapeutic use -- Periodicals; Plants, Medicinal -- Periodicals; 581.634
• DOI: 10.1002/ptr.5413
• Languages: English
• ISSNs: 0951-418X

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <italic>Lonicera japonica</italic> Thunb. (Caprifoliaceae) is a traditional herbal medicine and has been used to treat diabetic symptoms. Notwithstanding its use, the scientific basis on anti‐diabetic properties of <italic>L. japonica</italic> is not yet established. This study is designed to investigate anti‐diabetic effects of <italic>L. japonica</italic> in type 2 diabetic rats. <italic>L. japonica</italic> was orally administered at the dose of 100 mg/kg in high‐fat diet‐fed and low‐dose streptozotocin‐induced rats. After the treatment of 4 weeks, <italic>L. japonica</italic> reduced high blood glucose level and homeostatic model assessment of insulin resistance in diabetic rats. In addition, body weight and food intake were restored by the <italic>L. japonica</italic> treatment. In the histopathologic examination, the amelioration of damaged <italic>β</italic>‐islet in pancreas was observed in <italic>L. japonica</italic>‐treated diabetic rats. The administration of <italic>L. japonica</italic> elevated peroxisome proliferator‐activated receptor gamma and insulin receptor subunit‐1 protein expressions. The results demonstrated that <italic>L. japonica</italic> had anti‐diabetic effects in type 2 diabetic rats via the peroxisome proliferator‐activated receptor gamma regulatory action of <italic>L. japonica</italic> as a potential mechanism. Copyright © 2015 John Wiley & Sons, Ltd.</p> </abstract>