Alginate–Hydroxyapatite Bone Scaffolds with Isotropic or Anisotropic Pore Structure: Material Properties and Biological Behavior. Issue 10 (13th May 2015)

• Record Type: Journal Article
• Authors: Porrelli, Davide; Travan, Andrea; Turco, Gianluca; Marsich, Eleonora; Borgogna, Massimiliano; Paoletti, Sergio; Donati, Ivan
• Is Part Of: Macromolecular materials and engineering. Volume 300:Issue 10(2015:Oct.)
• Page Start: 989
• Page End: 1000
• Publication Date: 2015-05-13
• Subjects: Plastics -- Periodicals; Polymers -- Periodicals; Polymerization -- Periodicals; 547.705
• DOI: 10.1002/mame.201500055
• Languages: English
• ISSNs: 1438-7492

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <sec id="mame201500055-sec-0001" sec-type="section"> <p>Alginate/hydroxyapatite composites, with isotropic or anisotropic porosity, were developed using two different freezing methods. Morphological analysis highlighted the differences in their three‐dimensional network. Swelling and in vitro degradation studies revealed that both structures are highly hydrophilic and stable. Static compression tests showed that isotropic scaffolds possess higher modulus and toughness than anisotropic ones. Cyclic compression tests revealed that wet scaffolds are able to withstand high deformations with a peculiar shape‐recovery behaviour. In vitro biological tests showed that osteoblast‐like cells proliferate on both types of structures in a comparable manner.<inline-graphic xlink:href="ark:/27927/pgkfp5pv5p" content-type="mame201500055-gra-0001" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></p> </sec> </abstract>