Clinical, genomic, and metagenomic characterization of oral tongue squamous cell carcinoma in patients who do not smoke. Issue 11 (23rd August 2014)

• Record Type: Journal Article
• Authors: Li, Ryan; Faden, Daniel L.; Fakhry, Carole; Langelier, Chaz; Jiao, Yuchen; Wang, Yuxuan; Wilkerson, Matthew D.; Pedamallu, Chandra Sekhar; Old, Matthew; Lang, James; Loyo, Myriam; Ahn, Sun Mi; Tan, Marietta; Gooi, Zhen; Chan, Jason; Richmon, Jeremy; Wood, Laura D.; Hruban, Ralph H.; Bishop, Justin; Westra, William H.; Chung, Christine H.; Califano, Joseph; Gourin, Christine G.; Bettegowda, Chetan; Meyerson, Matthew; Papadopoulos, Nickolas; Kinzler, Kenneth W.; Vogelstein, Bert; DeRisi, Joseph L.; Koch, Wayne M.; Agrawal, Nishant;
• Is Part Of: Head & neck. Volume 37:Issue 11(2015:Nov.)
• Page Start: 1642
• Page End: 1649
• Publication Date: 2014-08-23
• Subjects: Head -- Diseases -- Periodicals; Neck -- Diseases -- Periodicals; Head -- Periodicals; Neck -- Periodicals; Face -- Periodicals; 617.51059
• DOI: 10.1002/hed.23807
• Languages: English
• ISSNs: 1043-3074

Abstract

<abstract abstract-type="main"> <title>Abstract</title> <sec id="hed23807-sec-0001" sec-type="section"> <title>Background</title> <p>Evidence suggests the incidence of oral tongue squamous cell carcinoma is increasing in young patients, many who have no history of tobacco use.</p> </sec> <sec id="hed23807-sec-0002" sec-type="section"> <title>Methods</title> <p>We clinically reviewed 89 patients with oral tongue cancer. Exomic sequencing of tumor DNA from 6 nonsmokers was performed and compared to previously sequenced cases. RNA from 20 tumors was evaluated by massively parallel sequencing to search for potentially oncogenic viruses.</p> </sec> <sec id="hed23807-sec-0003" sec-type="section"> <title>Results</title> <p>Non‐smokers (53 of 89) were younger than smokers (36 of 89; mean, 50.4 vs 61.9 years; <italic>p</italic> < .001), and seemed more likely to be women (58.5% vs 38.9%; <italic>p</italic> = .069). Nonsmokers had fewer <italic>TP53</italic> mutations (<italic>p</italic> = .02) than smokers. No tumor‐associated viruses were detected.</p> </sec> <sec id="hed23807-sec-0004" sec-type="section"> <title>Conclusion</title> <p>The young age of nonsmoking patients with oral tongue cancer and fewer <italic>TP53</italic> mutations suggest a viral role in this disease. Our efforts to identify such a virus were unsuccessful. Further studies are warranted to elucidate the drivers of carcinogenesis in these patients. © 2014 Wiley Periodicals, Inc. <italic>Head Neck</italic> 37: 1642–1649, 2015</p> </sec> </abstract>