Follicular variant of papillary thyroid carcinoma with B‐type RafV600E showing higher frequency of suspicious sonographic features and multifocality. Issue 11 (1st August 2014)

• Record Type: Journal Article
• Authors: Shin, Dong Yeob; Kim, Kwang Joon; Chang, Sooyun; Kim, Hyunki; Hwang, Sena; Kim, Wonjin; Bae, Jaehyun; Park, Seulkee; Kang, Sang‐Wook; Chung, Woong Youn; Lee, Eun Jig
• Is Part Of: Head & neck. Volume 37:Issue 11(2015:Nov.)
• Page Start: 1590
• Page End: 1595
• Publication Date: 2014-08-01
• Subjects: Head -- Diseases -- Periodicals; Neck -- Diseases -- Periodicals; Head -- Periodicals; Neck -- Periodicals; Face -- Periodicals; 617.51059
• DOI: 10.1002/hed.23793
• Languages: English
• ISSNs: 1043-3074

Abstract

<abstract abstract-type="main"> <title>Abstract</title> <sec id="hed23793-sec-0001" sec-type="section"> <title>Background</title> <p>The purpose of this study was to investigate the correlation between B‐type Raf (BRAF) kinase mutation and clinicopathological features of follicular variant of papillary thyroid carcinoma (PTC).</p> </sec> <sec id="hed23793-sec-0002" sec-type="section"> <title>Methods</title> <p>Eighty‐four patients with pathologically confirmed follicular variant of PTC, who underwent a preoperative BRAF<sup>V600E</sup> study, were analyzed. Clinicopathological parameters and ultrasonographic features were compared between the BRAF<sup>V600E</sup>‐positive and negative groups.</p> </sec> <sec id="hed23793-sec-0003" sec-type="section"> <title>Results</title> <p>A total of 41.7% of the patients showed BRAF<sup>V600E</sup>. The BRAF<sup>V600E</sup>‐positive group showed the smaller tumor size (7.3 ± 3.6 mm vs 10.7 ± 8.9 mm; <italic>p</italic> = .018) and the more frequent multifocality (25.7% vs 8.2%; <italic>p</italic> = .028). Follicular variant of PTC with BRAF<sup>V600E</sup> showed suspicious ultrasonographic features (88.6% vs 57.1%; <italic>p</italic> = .002) more frequently. BRAF<sup>V600E</sup> positivity is associated with multifocality after adjusting for age, sex, the presence of suspicious ultrasonographic features, pathological tumor size, and thyrotropin level.</p> </sec> <sec id="hed23793-sec-0004" sec-type="section"> <title>Conclusion</title> <p>BRAF<sup>V600E</sup> was correlated with smaller tumor size and suspicious ultrasonographic features in follicular variant of PTC. BRAF<sup>V600E</sup> was a significant parameter for predicting multifocality of follicular variant of PTC. © 2014 Wiley Periodicals, Inc. <italic>Head Neck</italic> 37: 1590–1595, 2015</p> </sec> </abstract>