Neurons and T cells: Understanding this interaction for inflammatory neurological diseases. Issue 10 (23rd September 2015)

• Record Type: Journal Article
• Authors: Yshii, Lidia; Gebauer, Christina; Bernard‐Valnet, Raphaël; Liblau, Roland
• Is Part Of: European journal of immunology. Volume 45:Issue 10(2015:Oct.)
• Page Start: 2712
• Page End: 2720
• Publication Date: 2015-09-23
• Subjects: Immunology -- Periodicals; 616.079
• DOI: 10.1002/eji.201545759
• Languages: English
• ISSNs: 0014-2980

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <p>Central nervous system (CNS) inflammation occurs in a large number of neurological diseases. The type and magnitude of CNS inflammation, as well as the T‐cell contribution, vary depending on the disease. Different animal models of neurological diseases have shown that T cells play an important role in CNS inflammation. Furthermore, recent studies of human neurological disorders have indicated a significant role for T cells in disease pathology. Nevertheless, how individual T‐cell subsets affect neuronal survival, damage and/or loss remains largely unclear. In this review we discuss the processes by which T cells mediate either beneficial or deleterious effects within the CNS, with emphasis on the direct interaction between T cells and neurons, as occurs in multiple sclerosis, paraneoplastic cerebellar degeneration, and viral encephalitis. The therapeutic approaches targeting T cells and their mediators as treatment for neurological diseases are also described here.</p> </abstract>