Simultaneous quantification of digoxin, digitoxin, and their metabolites in serum using high performance liquid chromatography‐tandem mass spectrometry. Issue 10 (4th March 2015)

• Record Type: Journal Article
• Authors: Bylda, Caroline; Thiele, Roland; Kobold, Uwe; Volmer, Dietrich A.
• Is Part Of: Drug testing and analysis. Volume 7:Issue 10(2015:Oct.)
• Page Start: 937
• Page End: 946
• Publication Date: 2015-03-04
• Subjects: Drugs -- Analysis -- Periodicals; Drug testing -- Periodicals; Chemistry, Forensic -- Periodicals; 615.1901
• DOI: 10.1002/dta.1781
• Languages: English
• ISSNs: 1942-7603

Abstract

<abstract abstract-type="graphical"> <title> <x xml:space="preserve">Abstract</x> </title> <p>The study describes an LC‐MS/MS method for simultaneous quantification of the cardiac glycosidic drugs digoxin and digitoxin and several of their metabolites. The assay represents a useful reference method for immunoassay‐based tests, which are easily biased by the presence of metabolites of the target analytes or structurally similar substances. <boxed-text content-type="graphic" id="dta1781-blkfxd-0001" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgkfn66z5w" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>