Are de novo rea(21;21) chromosomes really de novo?. Issue 10 (26th August 2015)

• Record Type: Journal Article
• Authors: Hervé, Bérénice; Quibel, Thibaud; Taieb, Stéphane; Ruiz, Mireille; Molina‐Gomes, Denise; Vialard, François
• Is Part Of: Clinical case reports. Volume 3:Issue 10(2015:Oct.)
• Page Start: 786
• Page End: 789
• Publication Date: 2015-08-26
• Subjects: Medicine -- Periodicals; 616.09
• DOI: 10.1002/ccr3.341
• Languages: English
• ISSNs: 2050-0904

Abstract

<abstract abstract-type="main" id="ccr3341-abs-0001"> <title>Key Clinical Message</title> <p>We report a rare case of recurrent trisomy 21 caused by an isochromosome 21q and what is very likely to be maternal germ‐line cell mosaicism. Over 90% of cases of rob(21;21) reported in the literature are due to an isochromosome 21q, with a risk of recurrence of more than 10%.</p> </abstract>