<abstract abstract-type="main" id="ccr3361-abs-0001"> <title>Key Clinical Message</title> <p>Aplasia cutis congenita is a disease in which skin, bone, and dura mater can be absent. In majority of the cases it affects the scalp. We report a baby girl born at term with a large scalp and skull defect measuring 9 × 10 cm. Conservative treatment led to complete epithelization.</p> </abstract>