1.25 Å resolution structure of an RNA 20‐mer that binds to the TREX2 complex. Issue 10 (1st October 2015)

• Record Type: Journal Article
• Authors: Valkov, Eugene; Stewart, Murray
• Is Part Of: Acta crystallographica. Volume 71:Issue 10(2015:Oct.)
• Page Start: 1318
• Page End: 1321
• Publication Date: 2015-10-01
• Subjects: Crystallography -- Periodicals; Crystals -- Periodicals; 548
• DOI: 10.1107/S2053230X1501643X
• Languages: English
• ISSNs: 2053-230X

Abstract

<abstract abstract-type="main" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p>The 1.25 Å resolution <italic>H</italic>32:<italic>R</italic> crystal structure of a 20 nt ribonucleotide that binds to the TREX‐2 complex with high affinity shows a double‐stranded RNA duplex arranged along a crystallographic 3₁ axis in which the antiparallel chains overlap by 18 nucleotides and are related by a crystallographic twofold axis. The duplex shows C–A, U–U and C–C noncanonical base pairings together with canonical Watson–Crick A–U and G–C pairs and a G–U wobble.</p> </abstract>