Antibacterial amphiphiles based on ε-polylysine: synthesis, mechanism of action, and cytotoxicity. Issue 85 (16th September 2015)

• Record Type: Journal Article
• Authors: Dai, Xiaomei; An, Jinxia; Wang, Yanan; Wu, Zhongming; Zhao, Yu; Guo, Qianqian; Zhang, Xinge; Li, Chaoxing
• Is Part Of: RSC advances. Volume 5:Issue 85(2015)
• Page Start: 69325
• Page End: 69333
• Publication Date: 2015-09-16
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c5ra10393b
• Languages: English
• ISSNs: 2046-2069

Abstract

<abstract abstract-type="toc"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <graphic position="anchor" id="ga" xlink:href="ark:/27927/pgj2rwbz3t6" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" />To combat antibiotic-resistant bacteria, an amphiphile based on ε-polylysine was synthesized <italic>via</italic> an alkylation reaction. The positively charged amphiphile could adsorb bacterial membranes, disrupt them and subsequently kill the bacteria.</p> </abstract>