Systemic Acute-phase Response in Laparoscopic and Open Ileal Pouch Anal Anastomosis in Patients With Ulcerative Colitis. Issue 5 (October 2015)

• Record Type: Journal Article
• Authors: Okita, Yoshiki; Araki, Toshimitsu; Hiro, Junichiro; Ide, Shozo; Imaoka, Hiroki; Kondo, Satoru; Kawamura, Mikio; Fujikawa, Hiroyuki; Inoue, Mikihiro; Toiyama, Yuji; Ohi, Masaki; Tanaka, Koji; Inoue, Yasuhiro; Uchida, Keiichi; Mohri, Yasuhiko; Kusunoki, Masato
• Is Part Of: Surgical laparoscopy endoscopy & percutaneous techniques. Volume 25:Issue 5(2015)
• Publication Date: 2015-10
• Subjects: Endoscopic surgery -- Periodicals; Laparoscopic surgery -- Periodicals; Endoscopy -- Periodicals; Laparoscopy -- Periodicals; 617.550597
• DOI: 10.1097/SLE.0000000000000128
• Languages: English
• ISSNs: 1530-4515

Abstract

<abstract> <title> <x xml:space="preserve">Abstract</x> </title> <sec> <title>Aim:</title> <p>The current trial was designed to study and compare the postoperative outcomes and systemic acute responses between patients undergoing laparoscopic-ileal pouch anal anastomosis (LAP-IPAA) and open IPAA for ulcerative colitis.</p> </sec> <sec> <title>Methods:</title> <p>The clinical records of patients who underwent 89 restorative proctocolectomy procedures with IPAA were reviewed. After determining which patients underwent LAP-IPAA versus open IPAA, an equivalent number of controls matched for age and ulcerative colitis severity were selected.</p> </sec> <sec> <title>Results:</title> <p>Twenty of 22 patients who underwent laparoscopic surgery met the inclusion criteria. Patients who underwent LAP-IPAA had significantly shorter times to first walking (<italic>P</italic>=0.021) and food intake (<italic>P</italic>=0.0003). The LAP-IPAA group had significantly lower interleukin-6 and interleukin-1ra levels soon after surgery (<italic>P</italic>=0.011 and <italic>P</italic>=0.0076). The LAP-IPAA group had significantly lower C-reactive protein levels on postoperative day 1 (<italic>P</italic>=0.0027).</p> </sec> <sec> <title>Conclusions:</title> <p>LAP-IPAA is a less-invasive operative procedure than open IPAA with respect to the postoperative systemic inflammatory response and postoperative recovery.</p> </sec> </abstract>