Efficacy of Endoscopic Mucosal Resection for Management of Small Duodenal Neuroendocrine Tumors. Issue 5 (October 2015)

• Record Type: Journal Article
• Authors: Shroff, Sagar R.; Kushnir, Vladimir M.; Wani, Sachin B.; Gupta, Neil; Jonnalagadda, Sreenivasa S.; Murad, Faris; Early, Dayna S.; Mullady, Daniel K.; Edmundowicz, Steven A.; Azar, Riad R.
• Is Part Of: Surgical laparoscopy endoscopy & percutaneous techniques. Volume 25:Issue 5(2015)
• Publication Date: 2015-10
• Subjects: Endoscopic surgery -- Periodicals; Laparoscopic surgery -- Periodicals; Endoscopy -- Periodicals; Laparoscopy -- Periodicals; 617.550597
• DOI: 10.1097/SLE.0000000000000192
• Languages: English
• ISSNs: 1530-4515

Abstract

<abstract> <title> <x xml:space="preserve">Abstract</x> </title> <sec> <title>Background:</title> <p>Endoscopic mucosal resection (EMR) for small (&lt;20 mm) duodenal neuroendocrine tumors (NETs) remains controversial because of their rarity.</p> </sec> <sec> <title>Materials and Methods:</title> <p>This is a retrospective cohort study of patients with surgically or endoscopically resected duodenal NETs from 2001 to 2011. The primary outcome is the rate of disease-free status following resection. A secondary outcome is the sensitivity of endoscopic ultrasound (EUS) in determining NET appropriateness for EMR.</p> </sec> <sec> <title>Results:</title> <p>Thirty patients underwent resection of duodenal NETs (EMR 20, surgery 10). Tumor was present at the margins in 40% of EMR-resected NETs and 10% of surgically resected NETs. Five patients who underwent EMR had residual disease treated with repeat EMR (3) and surgery (2). EUS demonstrated 96% sensitivity in determining lesions limited to the submucosa.</p> </sec> <sec> <title>Conclusions:</title> <p>EMR for small duodenal NETs can be a safe and effective alternative to surgery in carefully selected patients. EUS is a useful adjunct in determining depth of invasion for duodenal NETs.</p> </sec> </abstract>