Clinical and Prognostic Value of Depressive Symptoms and N-Terminal Pro–B-Type Natriuretic Peptide in Patients With Eisenmenger Syndrome. Issue 7 (September 2015)

• Record Type: Journal Article
• Authors: Moon, Ju Ryoung; Kang, Dae Ryong; Song, Jinyoung; Huh, June; Kang, I-Seok; Chang, Sung A.; Park, Seung Woo; Lee, Heung Jae
• Is Part Of: Psychosomatic medicine. Volume 77:Issue 7(2015)
• Publication Date: 2015-09
• Subjects: Medicine, Psychosomatic -- Periodicals; 616.0805
• DOI: 10.1097/PSY.0000000000000201
• Languages: English
• ISSNs: 0033-3174

Abstract

<abstract> <title>ABSTRACT</title> <sec> <title>Objectives</title> <p>Eisenmenger syndrome (ES) is commonly associated with depressive symptoms and elevated N-terminal pro–B-type natriuretic peptide (NT-proBNP). We investigated the predictive value of depressive symptoms and NTproBNP levels for long-term outcomes in patients with ES.</p> </sec> <sec> <title>Methods</title> <p>Blood was drawn to measure NT-proBNP, and depressive symptoms were measured using the Korean version of the Beck Depression Inventory (BDI) in an outpatient clinic sample of 64 patients with ES (67% female; median age = 41.5 years [range, 21.0–74.8 years]). Cardiac events (hospitalization, emergency department visits, and cardiac death) were monitored during 3 years of follow-up.</p> </sec> <sec> <title>Results</title> <p>During the follow-up period, 15 (23.4%) patients experienced a cardiac event. The combination of depressive symptoms and NT-proBNP levels better predicted future cardiac events than either variable alone. Patients with NT-proBNP &gt; 510 pg/ml and a total BDI score &gt; 10 had a 9.6 times higher risk for cardiac events than did patients with NT-proBNP ⩽ 510 pg/ml or total BDI score ⩽ 10 (<italic>p</italic> &lt; .001).</p> </sec> <sec> <title>Conclusions</title> <p>Depressive symptoms and NT-proBNP levels are both associated with adverse clinical outcomes in ES.</p> </sec> </abstract>