The Fc Receptor-Like 3 Polymorphisms (rs7528684, rs945635, rs3761959 and rs2282284) and The Risk of Neuromyelitis Optica in A Chinese Population. Issue 38 (September 2015)

• Record Type: Journal Article
• Authors: Lan, Wenjing; Fang, Shaokuan; Zhang, Huimao; Wang, Dan Tong Jianmeng; Wu, Jiang; Sahin., Alparslan
• Is Part Of: Medicine. Volume 94:Issue 38(2015)
• Publication Date: 2015-09
• Subjects: Medicine -- Periodicals; Medicine -- Periodicals; Médecine -- Périodiques; Geneeskunde; Medicine; Periodicals; Periodicals; 610.5
• DOI: 10.1097/MD.0000000000001320
• Languages: English
• ISSNs: 0025-7974

Abstract

<abstract> <title> <x xml:space="preserve">Abstract</x> </title> <sec> <title>Abstract</title> <p>Neuromyelitis optica (NMO) appears to be a severe inflammatory demyelinating disease occurring in the central nervous system. Furthermore, the Fc receptor-like 3 (<italic>FCRL3</italic>) gene was previously found to be susceptible for a certain inflammatory demyelinating diseases (such as multiple sclerosis). The present study, therefore, was aimed to explore the possible association of <italic>FCRL3</italic> gene polymorphisms with susceptibility to NMO in a Chinese Han population.</p> <p>Seven single nucleotide polymorphisms (SNPs) of <italic>FCRL3</italic> were, respectively, genotyped in 132 NMO patients and 264 healthy controls via PCR assay. Moreover, the <italic>t</italic>-test and the chi-square test were used to estimate the association between genetic mutations of <italic>FCRL3</italic> and the risk of NMO with Statistical Analysis System (SAS) software (Version 9.0).</p> <p>It was demonstrated that FCRL3_3, 5, 6 and 8, SNPs were remarkably associated with susceptibility to NMO in both allelic [OR = 1.50 (95% CI: 1.11–2.03, <italic>P</italic> = 0.008), OR = 1.44 (1.07–1.94, <italic>P</italic> = 0.015), OR = 1.45 (1.08–1.95, <italic>P</italic> = 0.014), and OR = 2.01 (1.13–3.60, <italic>P</italic> = 0.016)] and homozygous models [OR = 2.19 (95% CI: 1.19–3.99, <italic>P</italic> = 0.010), OR = 2.09 (1.15–3.80, <italic>P</italic> = 0.014), OR = 2.04 (1.13–3.67, <italic>P</italic> = 0.016), and OR = 5.33 (1.02–27.9, <italic>P</italic> = 0.027)]. However, the other 4 SNPs, FCRL3_4, FCRL3_7, FCRL3_9, did not show the significant associations with NMO.</p> <p>Conclusions in the present study could be drawn that 4 SNPs in <italic>FCRL3</italic> (FCRL3_3*C, 5*C, 6*A, 8*G) might account for increased risk of NMO in a Chinese-Han population. Nevertheless, further cohort studies are in demand to validate the association in the future.</p> </sec> </abstract>