Clinical Features and Outcomes of Pasteurella multocida Infection. Issue 36 (September 2015)

• Record Type: Journal Article
• Authors: Giordano, Antonio; Dincman, Toros; Clyburn, Benjamin E.; Steed, Lisa L.; Rockey, Don C.; Barbara, Adamik.
• Is Part Of: Medicine. Volume 94:Issue 36(2015)
• Publication Date: 2015-09
• Subjects: Medicine -- Periodicals; Medicine -- Periodicals; Médecine -- Périodiques; Geneeskunde; Medicine; Periodicals; Periodicals; 610.5
• DOI: 10.1097/MD.0000000000001285
• Languages: English
• ISSNs: 0025-7974

Abstract

<abstract> <title> <x xml:space="preserve">Abstract</x> </title> <sec> <title>Abstract</title> <p> <italic>Pasteurella multocida, </italic> a zoonotic infectious organism, has most often been described in patients after an animal bite. Here, we characterize the clinical features and outcomes of <italic>P multocida</italic> infection in a large cohort of patients according to the presence or absence of an animal bite.</p> <p>We retrospectively searched MUSC's laboratory information system for all patients with positive <italic>P multocida</italic> cultures from 2000 to 2014. Extensive data were abstracted, including clinical and outcome data. The Charlson comorbidity index (CCI) was used to assess comorbidities among patients.</p> <p>We identified 44 patients with <italic>P multocida</italic> infections, including 25 with an animal bite. The average age was 64 years and the majority of patients were women (N = 30). There was no difference in age and sex distribution among those with and without a bite (<italic>P</italic> = 0.38 and 0.75, respectively). A CCI ≥1 was significantly associated with the absence of a bite (<italic>P</italic> = 0.006). Patients presenting without a bite were more frequently bacteremic (37% vs 4%, respectively, <italic>P</italic> = 0.001), and were hospitalized more often (84% vs 44%, respectively, <italic>P</italic> = 0.012). Of the 8 patients who required intensive care unit (ICU)-based care, 7 were non-bite-related. There were 4 deaths, all occurring in patients not bitten.</p> <p> <italic>P multocida</italic> infections not associated with an animal bite were often associated with bacteremia, severe comorbidity(ies), immune-incompetent states, the need for ICU management, and were associated with substantial mortality.</p> </sec> </abstract>