Unexpected Anemia and Reticulocytopenia in an Adolescent With Sickle Cell Anemia Receiving Chronic Transfusion Therapy. Issue 7 (October 2015)

• Record Type: Journal Article
• Authors: Blauel, Emily R.; Grossmann, Lily T.; Vissa, Madhav; Miller, Scott T.
• Is Part Of: Journal of pediatric hematology/oncology. Volume 37:Issue 7(2015)
• Publication Date: 2015-10
• Subjects: Pediatric hematology -- Periodicals; Tumors in children -- Periodicals; 618.9215
• DOI: 10.1097/MPH.0000000000000410
• Languages: English
• ISSNs: 1077-4114

Abstract

<abstract> <title> <x xml:space="preserve">Abstract</x> </title> <sec> <p>In a patient with sickle cell disease receiving chronic transfusion, exacerbation of anemia with reticulocytopenia must prompt consideration of a delayed hemolytic transfusion reaction with hyperhemolysis, as further transfusion may worsen this condition; definitive diagnosis is sometimes difficult. Anemia evolving during parvovirus B19-induced erythroid hypoplasia (transient aplastic crisis) should be attenuated in chronic transfusion patients due to superior survival of transfused over endogenous red blood cells. A 16-year-old with sickle cell disease receiving chronic transfusion of modified intensity (goal to maintain hemoglobin S&lt;50%) who developed symptomatic anemia with reticulocytopenia was later shown to have had transient aplastic crisis.</p> </sec> </abstract>