Abdominal Paracentesis Drainage Does Not Increase Infection in Severe Acute Pancreatitis. Issue 9 (October 2015)

• Record Type: Journal Article
• Authors: Liu, Liye; Yan, Hongtao; Liu, Weihui; Cui, Jianfeng; Wang, Tao; Dai, Ruiwu; Liang, Hongyin; Luo, Hao; Tang, Lijun
• Is Part Of: Journal of clinical gastroenterology. Volume 49:Issue 9(2015)
• Publication Date: 2015-10
• Subjects: Gastroenterology -- Periodicals; Digestive organs -- Diseases -- Periodicals; Gastroenterology -- Periodicals; Digestive organs -- Diseases; Gastroenterology; Periodicals; Periodicals; 616.33005
• DOI: 10.1097/MCG.0000000000000358
• Languages: English
• ISSNs: 0192-0790

Abstract

<abstract> <title> <x xml:space="preserve">Abstract</x> </title> <sec> <title>Goals:</title> <p>To demonstrate the relationship between abdominal paracentesis drainage (APD) and infectious complications in moderately severe acute pancreatitis (MSAP) or severe acute pancreatitis (SAP) patients.</p> </sec> <sec> <title>Background:</title> <p>The effectiveness of APD for SAP was demonstrated in our previous study. However, the relationship between APD and infectious complications has not been fully elucidated.</p> </sec> <sec> <title>Study:</title> <p>We conducted a prospective cohort study of 255 patients with MSAP or SAP. The patients were divided into 2 groups: patients with acute pancreatitis who underwent APD (group 1) and patients with acute pancreatitis who did not undergo APD (group 2). Four types of infectious complications were evaluated: bacteremia, infected necrosis, pneumonia, and sepsis. The pathogens responsible for infectious complications were analyzed. The need for percutaneous catheter drainage and mortality were also compared between the 2 groups.</p> </sec> <sec> <title>Results:</title> <p>A total of 255 patients were included with analogous baseline features. The rate of overall infectious complications in group 1 was 38.1%, which was lower than that in group 2 (52.7%, <italic>P</italic>=0.019). This difference was mainly based on infected necrosis (12.7% and 23.3% in groups 1 and 2, respectively, <italic>P</italic>=0.034). The microbial spectrum was similar in the 2 groups. Percutaneous catheter drainage was used less frequent in group 1 (18.3%) than in group 2 (31.8%, <italic>P</italic>=0.014). The infection-related mortality in groups 1 and 2 was 6.5% and 8.5%, respectively, and there was no significant difference (<italic>P</italic>=0.457).</p> </sec> <sec> <title>Conclusion:</title> <p>Our results indicate that APD did not increase the infectious complications and infection-related mortality compared with the strategy without APD in patients with MSAP or SAP.</p> </sec> </abstract>