Clinical Utilization of Repeated Open Application Test Among American Contact Dermatitis Society Members. Issue 5 (September 2015)

• Record Type: Journal Article
• Authors: Brown, Gabrielle E.; Botto, Nina; Butler, Daniel C.; Murase, Jenny E.
• Is Part Of: Dermatitis. Volume 26:Issue 5(2015:Sep./Oct.)
• Publication Date: 2015-09
• Subjects: Skin -- Inflammation -- Periodicals; Skin -- Diseases -- Periodicals; Dermatology -- Periodicals; Dermatitis, Contact -- Periodicals; Dermatitis, Atopic -- Periodicals; Dermatitis, Occupational -- Periodicals; Drug Eruptions -- Periodicals; 616.51
• DOI: 10.1097/DER.0000000000000132
• Languages: English
• ISSNs: 1710-3568

Abstract

<abstract> <title> <x xml:space="preserve">Abstract</x> </title> <sec> <title>Background</title> <p>The repeated open application test (ROAT) provides useful information regarding allergens in suspected cases of allergic contact dermatitis; however, standardized methodology has not been established.</p> </sec> <sec> <title>Objective</title> <p>The aim of this study was to assess how ROAT is used in clinical and research settings.</p> </sec> <sec> <title>Methods</title> <p>We distributed a survey regarding ROAT practice to the American Contact Dermatitis Society and conducted a literature review of ROAT utilization in research.</p> </sec> <sec> <title>Results</title> <p>A total of 67 American Contact Dermatitis Society members participated in the survey. Respondents most frequently recommend application of leave-on products twice daily (46.0%) and rinse-off products once daily (43.5%). The most commonly used anatomical sites include the forearm (38.7%) and antecubital fossa (32.3%). Most respondents continue ROAT for 1 (49.2%) or 2 weeks (31.7%). Literature review of 32 studies (26 leave-on, 6 rinse-off) revealed that application frequency is most common at twice daily for both leave-on (96.2%) and rinse-off (50.0%) products. The most common anatomical site is the forearm (62.5%), with an overall study duration of 3 to 4 weeks (65.6%).</p> </sec> <sec> <title>Conclusions</title> <p>When comparing ROAT clinical and research practice, the majority trend was consistent for leave-on product application frequency and anatomical site, but not for rinse-off product application frequency, or overall duration. Further research is needed to determine best practice recommendations.</p> </sec> </abstract>