A pH‐Responsive Drug‐Delivery Platform Based on Glycol Chitosan–Coated Liposomes. Issue 37 (16th July 2015) - Yan, Lesan
Abstract pH‐responsive liposomes are prepared by conjugating glycol chitosan (GC) to the outer lipid membrane. This functionalization allows the liposomes to transition from a negative charge at physiologic pH to a positive charge in the acidic extracellular tumor microenvironment. Upon obtaining a positive charge, the GC‐liposomes loaded with doxorubicin exhibited enhanced cellular uptake and improved anticancer efficacy.